Global Disease Outbreaks: A 2025 Snapshot and Implications for the U.S.

DiseaseCountryRegion*Primary Category for Disease/TransmissionNumber of Cases/Deaths (as of date)Acute febrile illnessDemocratic Republic of the CongoSub-Saharan AfricaNot applicable1,318 suspected cases, inc. 53 deaths (as of Feb. 25)AnthraxDemocratic Republic of the CongoSub-Saharan AfricaDirect contact infection17 suspected cases, inc. 1 death (as of April 30)ThailandEast Asia and the Pacific5 confirmed cases, inc. 1 death (as of May 28)UgandaSub-Saharan Africa15 confirmed cases, inc. 2 deaths (as of March 30)Avian InfluenzaCambodiaEast Asia and the PacificRespiratory infectionCambodia: 11 confirmed cases, inc. 6 deaths (as of July 1)
Mexico: 1 confirmed case, inc. 1 death (as of April 2)MexicoWestern HemisphereChapare hemorrhagic feverBoliviaWestern HemisphereDirect contact infection1 confirmed case, inc. 1 death (as of Jan. 13)ChikungunyaKey countries:
BangladeshSouth and Central AsiaVector-borne infectionGlobal overview: 445,271 (263,592 suspected and 181,679 confirmed) cases, inc. 155 deaths (as of Sept. 30)
Indian Ocean countries: data not provided (as of Sept. 5)
Bolivia: data not provided (as of June 26)
Cuba: data not provided (as of Sept. 26)
La Réunion and Mayotte (France): in La Réunion, over 47,500 confirmed cases, but more than 170,000 consultations for suspected chikungunya, and at least 12 deaths, with more suspected; in Mayotte, 116 cases (as of May 4)BoliviaWestern HemisphereChinaEast Asia and the PacificCubaWestern HemisphereKenyaSub-Saharan AfricaLa Réunion and Mayotte (France)Sub-Saharan AfricaMadagascarSub-Saharan AfricaSomaliaSub-Saharan AfricaSri LankaSouth and Central AsiaCholeraAfghanistanSouth and Central AsiaFood-/waterborne infectionGlobal overview: 489,452 cholera/Acute Watery Diarrhea cases; 6,155 deaths (as of Sept. 26; earlier alert)AngolaSub-Saharan AfricaBangladeshSouth and Central AsiaBurundiSub-Saharan AfricaChadSub-Saharan AfricaCote d’IvoireSub-Saharan AfricaDemocratic Republic of the CongoSub-Saharan AfricaEthiopiaSub-Saharan AfricaGhanaSub-Saharan AfricaHaitiWestern HemisphereIndiaSouth and Central AsiaIraqNear EastKenyaSub-Saharan AfricaMalawiSub-Saharan AfricaMozambiqueSub-Saharan AfricaMyanmarEast Asia and the PacificNamibiaSub-Saharan AfricaNepalSouth and Central AsiaNigerSub-Saharan AfricaNigeriaSub-Saharan AfricaPakistanSouth and Central AsiaPhilippinesEast Asia and the PacificRepublic of the CongoSub-Saharan AfricaRwandaSub-Saharan AfricaSomaliaSub-Saharan AfricaSouth SudanSub-Saharan AfricaSudanSub-Saharan AfricaTanzaniaSub-Saharan AfricaThailandEast Asia and the PacificTogoSub-Saharan AfricaUgandaSub-Saharan AfricaYemenNear EastZambiaSub-Saharan AfricaZimbabweSub-Saharan AfricaDengueUnited States of AmericaWestern HemisphereVector-borne infectionOutbreaks in various areas (as of July 29); 2,560 locally acquired cases (as of Sept. 25)Ebola virus disease (EVD) (inc. Sudan virus disease, SVD)Democratic Republic of the Congo

Uganda

Sub-Saharan AfricaDirect contact infectionEVD: 64 suspected (53 confirmed and 11 probable) cases, inc. 43 deaths (as of Oct. 5; earlier alert)

SVD: 14 cases – 12 confirmed, 2 probable – inc. 4 deaths – 2 confirmed, 2 probable (as of April 26)

Invasive meningococcal diseaseSaudi ArabiaNear EastDirect contact infection17 cases (as of April 11)Marburg virus disease TanzaniaSub-Saharan AfricaDirect contact infection10 suspected (2 confirmed, 8 probable) cases, inc. 10 deaths (as of March 12)MeaslesArgentinaWestern HemisphereRespiratory infectionRegion of the Americas (inc. United States of America): 10,139 confirmed cases, inc. 18 deaths (as of Aug. 8; earlier alert)
Morocco: more than 25,000 suspected cases, inc. 13,706 confirmed cases and 184 deaths, from Oct. 2023 through April 13, 2025 (as of May 13)
United States of America: 1,544 cases, inc. 3 deaths (as of Sept. 30)BelizeWestern HemisphereBoliviaWestern HemisphereBrazilWestern HemisphereCanadaWestern HemisphereCosta RicaWestern HemisphereMexicoWestern HemisphereMoroccoNear EastParaguayWestern HemispherePeruWestern HemisphereUnited States of AmericaWestern HemisphereMiddle East respiratory syndrome (MERS) coronavirusSaudi ArabiaNear EastRespiratory infection9 confirmed cases, inc. 2 deaths (as of April 21)MpoxKey countries:
Burundi
Democratic Republic of the Congo
Kenya
Rwanda
Sierra Leone
UgandaSub-Saharan AfricaDirect contact infectionGlobal overview: 38,671 confirmed cases, inc. 163 deaths (as of Aug. 31; earlier alert)Nipah virusBangladesh
IndiaSouth and Central AsiaDirect contact infectionBangladesh: 4 confirmed cases, inc. 4 deaths (as of Aug. 29)
India: 4 confirmed cases, inc. 2 deaths (as of July 12)Oropouche virus diseaseKey countries:
Brazil
PanamaWestern HemisphereVector-borne infectionData not provided (as of July 14); Americas Region overview: 12,786 confirmed cases (as of July 27)RabiesTimor-LesteEast Asia and the PacificDirect contact infection4 confirmed cases, inc. 4 deaths (as of June 17)Rift Valley FeverSenegalSub-Saharan AfricaVector-borne infectionData not provided (as of Oct. 10)Variant Poliovirus (i.e., circulating vaccine-derived poliovirus of three types: cVDPV1, cVDPV2, cVDPV3)cVDPV1:
AlgeriaNear EastFood-/waterborne infectioncVDPV1 global overview: 2 cases of acute flaccid paralysis (as of Oct. 6)
 
cVDPV2 global overview: 146 cases of acute flaccid paralysis (as of Oct. 6)
 
cVDPV3 global overview: 5 cases of acute flaccid paralysis (as of Oct. 6)Democratic Republic of the CongoSub-Saharan AfricacVDPV2:
AngolaSub-Saharan AfricaBeninSub-Saharan AfricaBurkina FasoSub-Saharan AfricaCentral African RepublicSub-Saharan AfricaChadSub-Saharan AfricaDjiboutiSub-Saharan AfricaEthiopiaSub-Saharan AfricaNigerSub-Saharan AfricaNigeriaSub-Saharan AfricaPapua New GuineaEast Asia and the PacificSomaliaSub-Saharan AfricaSudanSub-Saharan AfricaYemenNear EastcVDPV3:
CameroonSub-Saharan AfricaChadSub-Saharan AfricaGuineaSub-Saharan AfricaYellow fever Bolivia
Brazil
Colombia
Ecuador
PeruWestern HemisphereVector-borne infection235 confirmed cases, inc. 96 deaths (as of May 25; earlier alert)Zika virus diseaseIndiaSouth and Central AsiaVector-borne infection151 cases in 2024 (as of Jan. 29)Note: * Regions reflect those used by the U.S. State Department; Near East includes the Middle East and North Africa. Disease outbreaks as identified and defined by the following authoritative sources: WHO, CDC, and GPEI; not an exhaustive list of outbreaks globally. As of Oct. 10, 2025. Does not include diseases such as COVID-19, wild poliovirus, and seasonal influenza where there have not been unexpected levels of cases and deaths this year.

Sources: WHO, Disease Outbreak News, Situation Reports, and Rapid Risk Assessment Reports; CDC, Outbreak webpage; CDC, Travel Notices webpage; GPEI, Polio This Week.